来自南太平洋萨摩亚群岛的体育记者杜克（约翰尼·德普 Johnny Depp 饰）和他的律师朋友刚佐博士（本尼西奥·德·托尔 Benicio Del Tore 饰）一起开车前往拉斯维加斯，寻找他们的“美国梦”。一路上，他们带了大量毒品和酒精，也遇到形形色色的人，药物作用下，许多迷乱和癫狂的画面出现，让他们分不清幻觉和现实，到底哪个更残破，哪个更肮脏扭…
A rich man leaves all his wealth to his most loved Ex-girlfriend. But at his wake, five exes pay their respects by sharing their wild and naughty moments. Who among them will be his heir?
When Paula leaves Rio de Janeiro to resume her work as a volunteer doctor in the Amazon, Teto hatches an impulsive plan to follow her and chaos ensues.
