Perry, a mattress store manager, hatches a wild plan to impress the girl of his dreams, but his efforts go off the rails when his fake kidnapping of her brother gets more complicated than he expected.

　　Seth Meyers和Mike O’Brien制作的喜剧《疯狂教授生物课 A.P. Bio》讲述一名前哲学系教授（Glenn Howerton饰）失去梦寐以求的工作后，只好去到高中接受一份教授大学预修生物学课程的工作，但明确表示不会教授任何生物学的他，决定利用这群优等生来报复在主角人生中冤枉他的人。

本片由多个恐怖而有趣的小故事组成